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Actor Christina Applegate reveals she was misdiagnosed with multiple sclerosis

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This story was selected and curated by our editorial team in the Christina Applegate category. Published on October 20, 2026 • Originally reported by Richard Luscombe. OMEGAZEPRIME provides independent news coverage and analysis for our readers. Stay informed with the latest developments.

The Married … with Children actor says the news is ‘unnerving’ and ‘really confusing’

After becoming a prominent advocate for multiple sclerosis awareness and chronicling her struggles in an emotional memoir published in March, the Emmy-winning actor Christina Applegate has revealed she does not have the debilitating autoimmune disease after all.

Applegate, 54, made the stunning announcement in an episode of her podcast MeSsy, recorded with fellow actor Jamie-Lynn Sigler, posted to YouTube on Tuesday.

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